Piperacillin + Tazobactam
Brand: Zosyn (US/EU) / Pipzo (IN) / Piptaz (BD)
Antibiotic
Extended-spectrum penicillin + β-lactamase inhibitor
Chemistry
Structure
Pharmacokinetics
| Half-life | 1 hours |
| Tmax | 0.5 h |
| Bioavailability | 70 % (approx) |
| Protein Binding | 30 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | PK simplified for calculator: piperacillin component only. Typical dosing 4.5 g IV q6h (4 g/0.5 g). |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Diarrhea, rash, thrombocytopenia, electrolyte imbalance (hypokalemia)
Contraindications:
Severe penicillin allergy
Precautions:
Dose adjust in renal impairment; monitor electrolytes in long courses