Streptomycin
Brand: Streptomycin (global) / Streptopen (IN) / Strepto (BD)
Antibiotic
Anti-TB (aminoglycoside)
Pharmacokinetics
| Half-life | 2.5 hours |
| Tmax | 0.5 h |
| Bioavailability | 100 % (approx) |
| Protein Binding | 35 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Therapeutic drug monitoring where available; strong renal clearance—adjust in CKD. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Ototoxicity (vestibular > cochlear), nephrotoxicity, neuromuscular blockade
Contraindications:
Myasthenia gravis
Precautions:
Avoid concurrent other ototoxic/nephrotoxic drugs; monitor renal function and hearing