Clofazimine
Brand: Lamprene (global) / Clofaz (IN/BD)
Antibiotic
Anti-TB (riminophenazine)
Pharmacokinetics
| Half-life | 70 days |
| Tmax | 8 h |
| Bioavailability | 70 % (approx) |
| Protein Binding | 90 % |
| Volume of Distribution | 150 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Extremely long half-life; accumulates in tissues; causes reversible red-brown skin discoloration. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Skin discoloration red→brown→black, GI pain, photosensitivity
Contraindications:
Severe hepatic disease
Precautions:
Counsel patients about discoloration (cosmetic impact significant)