Ethionamide

Brand: Trecator (global) / Ethide (IN/BD)

Antibiotic Anti-TB (isonicotinic acid thioamide)

Chemistry

Molecular Formula	C8H10N2S
PubChem	CID: 2761171 Open in PubChem

Structure

Half-life	2 hours
Tmax	3 h
Bioavailability	70 % (approx)
Protein Binding	30 %
Volume of Distribution	0.5 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	yes
Notes	Causes severe GI intolerance (metallic taste, nausea); supplement B6 same as INH.

Severity: Moderate

Adverse Effects:
Nausea, metallic taste, hepatotoxicity, hypothyroidism

Contraindications:
Severe hepatic impairment

Precautions:
Give pyridoxine; monitor TSH periodically, especially if combined with para-aminosalicylic acid