Bevacizumab
Brand: Avastin (global) / Bevacizumab (IN/BD)
Anticancer
VEGF monoclonal antibody
Pharmacokinetics
| Half-life | 480 hours |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | RAW70: Reference Adult Weight 70 kg. Max 15 mg/kg every 21d ≈ 1050 mg/dose. Divide dose weekly/daily if needed for calculator. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
Hypertension, proteinuria, arterial thromboembolism, GI perforation
Contraindications:
High bleeding risk or recent major surgery
Precautions:
Monitor BP, urine protein; withhold before abdominal surgery