Vinblastine

Brand: Velbe (global) / Cytoblastin (IN/BD)

Anticancer Vinca alkaloid (microtubule inhibitor)

Chemistry

Molecular Formula	C46H58N4O9
PubChem	CID: 6917775 Open in PubChem

Structure

Half-life	25 hours
Clearance Route	hepatic
Active Metabolites	no
Notes	Dose limiting toxicity is bone marrow suppression.

Severity: Severe

Adverse Effects:
Myelosuppression, hair loss, nausea/vomiting

Contraindications:
Severe neutropenia

Precautions:
Monitor CBC weekly; avoid intrathecal administration.