Oxaliplatin

Brand: Eloxatin (global)

Anticancer Platinum compound (DNA crosslinker)

Chemistry

Molecular Formula	C8H14N2O4Pt
PubChem	CID: 5351550 Open in PubChem

Structure

Half-life	14 hours
Clearance Route	renal
Active Metabolites	yes
Notes	Peripheral neuropathy worsened by cold exposure; counsel patient to avoid cold drinks/ice.

Severity: Moderate

Adverse Effects:
Peripheral neuropathy (cold induced), nausea/vomiting, diarrhea, myelosuppression

Contraindications:
Severe renal impairment

Precautions:
Avoid cold exposure; dose reduction in neuropathy; monitor CBC