Capecitabine

Brand: Xeloda (global)

Anticancer Antimetabolite (oral prodrug of 5-FU)

Chemistry

Molecular Formula	C15H22FN3O6
PubChem	CID: 60953 Open in PubChem

Structure

Half-life	0.75 hours
Clearance Route	hepatic
Active Metabolites	yes
Notes	Hand-foot syndrome more common vs IV 5-FU; dose modify in renal impairment; avoid in DPD deficiency.

Severity: Severe

Adverse Effects:
Diarrhea, hand-foot syndrome, mucositis, fatigue, cardiotoxicity (rare)

Contraindications:
Severe renal impairment, known DPD deficiency

Precautions:
Monitor renal function; counsel about hand-foot care; stop for grade 3/4 diarrhea