Argatroban

Brand: Argatroban (US/EU) / Argihope (IN) / Argiprax (IN) / Argatro (BD)

Anticoagulant Direct thrombin inhibitor (parenteral)

Chemistry

Molecular Formula	C23H36N6O5S
PubChem	CID: 60854 Open in PubChem

Structure

Half-life	1 hours
Tmax	0 h
Protein Binding	54 %
Volume of Distribution	0.18 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	no
Notes	Hepatically cleared; preferred anticoagulant in HIT patients with renal failure; prolongs INR which complicates warfarin bridging.

Severity: Severe

Adverse Effects:
Bleeding, hypotension, infusion-related reactions, elevated INR during therapy

Contraindications:
Active major bleeding, severe hepatic impairment

Precautions:
Monitor aPTT; preferred in HIT with renal failure; caution when transitioning to warfarin due to INR distortion