Bivalirudin
Brand: Angiomax (US/EU) / Bivasave (IN) / Bivacard (IN) / Bivaplex (BD)
Anticoagulant
Direct thrombin inhibitor (parenteral, procedural)
Pharmacokinetics
| Half-life | 0.5 hours |
| Tmax | 0 h |
| Protein Binding | 25 % |
| Volume of Distribution | 0.14 L/kg (approx) |
| Clearance Route | mixed |
| Active Metabolites | no |
| Notes | Cleared by proteolytic cleavage and partially renal; extremely short half-life; used during PCI due to rapid offset. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Bleeding, hypotension, procedural hematoma
Contraindications:
Active bleeding, severe uncontrolled hypertension
Precautions:
Dose adjust in renal impairment; preferred over heparin in HIT undergoing PCI; no specific antidote