Perampanel
Brand: Fycompa (US/EU) / Perampanel (IN/BD)
Anticonvulsant
AMPA receptor antagonist
Chemistry
| PubChem |
CID: 9924495 |
Structure
Pharmacokinetics
| Half-life | 105 hours |
| Bioavailability | 100 % (approx) |
| Protein Binding | 95 % |
| Volume of Distribution | 1.1 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | uncertain |
| Notes | Long t½; strong interactions with enzyme inducers (CBZ, PHT, OXC) ↓ levels; titrate slowly to minimize neuropsychiatric AEs. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Dizziness, somnolence, ataxia, irritability, aggression, falls
Contraindications:
Severe hepatic impairment
Precautions:
Caution with psychiatric history; monitor mood/behavior; dose adjust with strong CYP3A inducers/inhibitors.