Sertraline
Brand: Zoloft (US/EU) / Serlift (IN) / Sertral (BD)
Antidepressant
SSRI (Selective serotonin reuptake inhibitor)
Pharmacokinetics
| Half-life | 26 hours |
| Tmax | 6 h |
| Bioavailability | 44 % (approx) |
| Protein Binding | 98 % |
| Volume of Distribution | 20 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Week 1 dose titration recommended; metabolized via CYP2B6, CYP2D6, CYP3A4. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
GI upset, insomnia, sexual dysfunction, headache, agitation
Contraindications:
Concomitant MAOI use (risk of serotonin syndrome)
Precautions:
Monitor for suicidal ideation early therapy; caution with other serotonergic drugs; avoid abrupt stop.