Bupropion
Brand: Wellbutrin (US/EU) / Bupep (IN) / Buproton (BD)
Antidepressant
NDRI (Norepinephrine-Dopamine Reuptake Inhibitor)
Pharmacokinetics
| Half-life | 21 hours |
| Tmax | 2 h |
| Bioavailability | 5 % (approx) |
| Protein Binding | 84 % |
| Volume of Distribution | 19 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Lower seizure threshold; avoid in eating disorders (bulimia, anorexia). Useful in SSRI sexual dysfunction substitution. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Insomnia, agitation, tremor, dry mouth, seizures (dose dependent)
Contraindications:
Seizure disorder, eating disorders, abrupt alcohol or benzo withdrawal
Precautions:
Avoid doses >450 mg/day; caution with other drugs lowering seizure threshold.