Gliclazide
Brand: Diamicron (US/EU) / Glynase (IN) / Gliclade (BD)
Antidiabetic
Sulfonylurea (insulin secretagogue)
Pharmacokinetics
| Half-life | 12 hours |
| Tmax | 4 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 85 % |
| Volume of Distribution | 0.3 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Use MR (modified release) daily; reduce dose in elderly/CKD to limit hypoglycemia. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Hypoglycemia, weight gain, rash (rare)
Contraindications:
Type 1 diabetes, DKA, significant sulfa allergy (relative)
Precautions:
Educate on hypoglycemia; consider lower starting dose in elderly or CKD