Lixisenatide
Brand: Adlyxin / Lyxumia
Antidiabetic
GLP-1 receptor agonist (once-daily)
Pharmacokinetics
| Half-life | 3 hours |
| Tmax | 1.5 h |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Short half-life (~3 h) supports once-daily dosing; primarily renally eliminated; avoid/caution in significant renal impairment. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Nausea, vomiting, diarrhea, dizziness, headache
Contraindications:
Severe hypersensitivity; caution in severe renal impairment
Precautions:
Pancreatitis risk; delays gastric emptying; hypoglycemia mainly with insulin/sulfonylureas; caution with gastroparesis