Prazosin
Brand: Minipress (US/EU) / Prazopress (IN) / Prazo (BD)
Antihypertensive
Selective α₁-adrenergic blocker
Pharmacokinetics
| Half-life | 3 hours |
| Tmax | 2 h |
| Bioavailability | 60 % (approx) |
| Protein Binding | 97 % |
| Volume of Distribution | 0.5 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Undergoes extensive first-pass metabolism; short duration of action; may cause first-dose postural hypotension; usually given at bedtime initially. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Postural hypotension, dizziness, headache, palpitations, nasal congestion
Contraindications:
History of orthostatic hypotension
Precautions:
Start with low bedtime dose; rise slowly from sitting/lying position; caution in elderly and heart failure