Pramipexole
Brand: Mirapex (US/EU) / Pramirol (IN) / Pexola (BD)
Antiparkinson
Dopamine agonist (D2/D3)
Pharmacokinetics
| Half-life | 10 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 15 % |
| Volume of Distribution | 2.5 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Dose adjust required in renal impairment. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Nausea, orthostatic hypotension, hallucinations, impulse control disorders (gambling, hypersexuality)
Contraindications:
Known hypersensitivity
Precautions:
Monitor for behavioral changes; caution in elderly; caution in renal impairment