Entacapone
Brand: Comtan (US/EU) / Entacom (IN) / Enta (BD)
Antiparkinson
COMT inhibitor
Pharmacokinetics
| Half-life | 1 hours |
| Tmax | 0.8 h |
| Bioavailability | 35 % (approx) |
| Protein Binding | 98 % |
| Volume of Distribution | 0.3 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Must be given with levodopa; not useful alone. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Diarrhea, orange discoloration of urine, dyskinesias (due to ↑ levodopa effect)
Contraindications:
Hepatic failure history
Precautions:
Monitor for increased levodopa side effects