Risperidone
Brand: Risperdal (US/EU) / Sizodon (IN) / Risp (BD)
Antipsychotic
Atypical antipsychotic (D2/5-HT2A antagonist)
Pharmacokinetics
| Half-life | 20 hours |
| Tmax | 1 h |
| Bioavailability | 70 % (approx) |
| Protein Binding | 90 % |
| Volume of Distribution | 1.5 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Active metabolite: paliperidone; high prolactin raising tendency among atypicals. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Hyperprolactinemia, weight gain, metabolic syndrome, extrapyramidal symptoms, sedation
Contraindications:
Known hypersensitivity
Precautions:
Monitor weight, lipids, glucose; caution in elderly dementia (increased mortality risk).