Pravastatin
Brand: Pravachol (US/EU) / Pravator (IN) / Vastatin (BD)
Cardiovascular
Statin (HMG-CoA reductase inhibitor)
Pharmacokinetics
| Half-life | 1.8 hours |
| Tmax | 1.5 h |
| Bioavailability | 17 % (approx) |
| Protein Binding | 50 % |
| Volume of Distribution | 0.4 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Hydrophilic; minimal CYP metabolism; lower drug interaction profile. |
⚠️ Safety & Warnings
Severity: Mild
Adverse Effects:
Mild transaminitis, headache, mild GI upset
Contraindications:
Pregnancy, active liver disease
Precautions:
Preferred in patients at higher risk of drug interactions or hepatic impairment