Naloxone
Brand: Narcan (US/EU) / Nalox (IN/BD)
Emergency
Opioid antagonist
Pharmacokinetics
| Half-life | 1 hours |
| Tmax | 0.25 h |
| Bioavailability | 2 % (approx) |
| Protein Binding | 34 % |
| Volume of Distribution | 2 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Duration shorter than many opioids—monitor for re-sedation; infusion may be needed for long-acting opioids. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
Acute withdrawal in opioid-dependent patients, agitation, hypertension
Contraindications:
None in emergency overdose
Precautions:
Observe patient minimum 2 hours; repeat doses may be required with long-acting opioids