Megestrol Acetate

Brand: Megace (US/EU) / Megetrol (IN) / Megace (BD)

Endocrine Progestin (appetite stimulant)

Chemistry

Molecular Formula	C24H32O4
PubChem	CID: 11683 Open in PubChem

Structure

Half-life	20 hours
Clearance Route	hepatic
Active Metabolites	yes
Notes	Used as appetite stimulant in wasting syndrome. Dose varies widely; 400–800 mg/day typical. Does not treat tumour.

Severity: Severe

Adverse Effects:
Thromboembolism, adrenal suppression, edema, hyperglycemia

Contraindications:
Estrogen/progestin dependent cancers caution; active DVT/PE

Precautions:
Long-term use may cause adrenal axis suppression; tapering needed after prolonged therapy