Mesalazine
Brand: Asacol (US/EU) / Pentasa (US/EU) / Mesacol (IN) / Salofalk (BD)
Gastrointestinal
5-Aminosalicylic acid (anti-inflammatory)
Pharmacokinetics
| Half-life | 1 hours |
| Tmax | 1.5 h |
| Bioavailability | 30 % (approx) |
| Protein Binding | 50 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | yes |
| Notes | Acts locally in gut; minimal systemic absorption; acetylated to inactive N-acetyl-5-ASA and excreted in urine. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Headache, nausea, abdominal pain, diarrhea; rare nephrotoxicity, myocarditis
Contraindications:
Severe renal impairment, salicylate hypersensitivity
Precautions:
Monitor renal function periodically; caution in patients with renal disease