Racecadotril
Brand: Hidrasec / Redotil / Racecadotril
Gastrointestinal
Antisecretory antidiarrheal (Enkephalinase inhibitor)
Pharmacokinetics
| Half-life | 3 hours |
| Tmax | 1 h |
| Protein Binding | 90 % |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Prodrug rapidly converted to active metabolite thiorphan. Reduces intestinal secretion without causing significant constipation. Common adult dose: 100 mg three times daily. |
⚠️ Safety & Warnings
Severity: Mild
Adverse Effects:
Headache, nausea, abdominal discomfort, rash (rare)
Contraindications:
Hypersensitivity to racecadotril or formulation components
Precautions:
Not a substitute for oral rehydration therapy. Seek evaluation in bloody diarrhea, high fever, severe dehydration, or prolonged symptoms.