| Half-life | 20 hours |
| Clearance Route | hepatic |
| Active Metabolites | minor |
| Notes | COX-2 preferential; safer GI profile vs. piroxicam; avoid in renal impairment and volume depletion. |
Severity: Moderate
Adverse Effects:
Dyspepsia, nausea, edema, increased BP, renal impairment; rare SJS/TEN
Contraindications:
Active GI ulcer/bleed, NSAID hypersensitivity, severe renal/hepatic failure, late pregnancy
Precautions:
Monitor BP, renal function; avoid combination with other NSAIDs; caution in elderly