Gabapentin
Brand: Neurontin (US/EU) / Gabastar (IN) / Gabamax (BD)
Neurological
Anti-epileptic / Neuropathic pain
Pharmacokinetics
| Half-life | 6 hours |
| Tmax | 3 h |
| Bioavailability | 60 % (approx) |
| Protein Binding | 0 % |
| Volume of Distribution | 0.6 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Absorption saturable—bioavailability decreases with higher doses. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Sedation, dizziness, peripheral edema
Contraindications:
Severe renal failure
Precautions:
Reduce dose in renal impairment; avoid alcohol/CNS depressants