Pregabalin
Brand: Lyrica (US/EU) / Pregaba (IN/BD)
Neurological
Neuropathic pain / Central sensitization
Pharmacokinetics
| Half-life | 6 hours |
| Tmax | 1 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 0 % |
| Volume of Distribution | 0.5 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Schedule V in many regions; strong anxiolytic; taper slowly to avoid withdrawal. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Dizziness, sedation, euphoria, edema, weight gain
Contraindications:
Severe renal failure
Precautions:
Risk of dependence; caution with opioids/benzos