Piracetam
Brand: Nootropil (EU) / Piracetam (IN) / Lucetam (BD)
Neurological
Nootropic (GABA analog, neuronal membrane modulator)
Pharmacokinetics
| Half-life | 5 hours |
| Tmax | 1 h |
| Bioavailability | 100 % (approx) |
| Protein Binding | 0 % |
| Volume of Distribution | 0.6 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Not metabolized; excreted unchanged by kidneys; dose reduction required in renal impairment. |
⚠️ Safety & Warnings
Severity: Mild
Adverse Effects:
Nervousness, insomnia, agitation, weight gain, GI upset
Contraindications:
Severe renal failure, Huntington disease
Precautions:
Adjust dose in renal impairment; discontinue gradually to avoid rebound myoclonus