Temazepam
Brand: Restoril (US) / Temsun (IN) / Restozam (BD)
Sedative/Hypnotic
Benzodiazepine hypnotic (GABA-A positive allosteric modulator)
Pharmacokinetics
| Half-life | 10 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 95 % |
| Volume of Distribution | 1 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Lower next-day sedation compared to longer acting benzodiazepines; avoid alcohol and opioids. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Daytime drowsiness, impaired coordination, memory impairment, dependency
Contraindications:
Respiratory depression, sleep apnea, concomitant alcohol use
Precautions:
Use minimal effective dose; avoid in elderly when possible (high fall risk); taper slowly to avoid withdrawal.