Olanzapine

Brand: Zyprexa (US/EU) / Olzap (IN) / Olanzin (BD)

Antipsychotic Atypical antipsychotic (D2/5-HT2A antagonist)

Chemistry

Molecular Formula	C17H20N4S
PubChem	CID: 4585 Open in PubChem

Structure

Half-life	30 hours
Tmax	6 h
Bioavailability	60 % (approx)
Protein Binding	93 %
Volume of Distribution	25 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	yes
Notes	Very high metabolic side effect profile: weight gain, diabetes, dyslipidemia.

Severity: Severe

Adverse Effects:
Severe weight gain, increased appetite, hyperglycemia, dyslipidemia, sedation, orthostatic hypotension

Contraindications:
Known hypersensitivity

Precautions:
Monitor weight, fasting glucose, HbA1c, lipids routinely; avoid in diabetes patients unless necessary.