Glipizide
Brand: Glucotrol (US) / Glip (IN) / Gliplon (BD)
Antidiabetic
Sulfonylurea (insulin secretagogue)
Pharmacokinetics
| Half-life | 2.5 hours |
| Tmax | 1 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 98 % |
| Volume of Distribution | 0.1 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Shorter half-life → lower nighttime hypoglycemia vs glibenclamide. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Hypoglycemia, weight gain, dizziness, rash
Contraindications:
Type 1 DM, DKA
Precautions:
Use lowest dose in elderly; educate on hypoglycemia