Insulin Degludec
Brand: Tresiba (US/EU)
Antidiabetic
Ultra-long basal insulin
Chemistry
| Molecular Formula | Peptide |
Structure
Pharmacokinetics
| Half-life | 25 hours |
| Tmax | 12 h |
| Bioavailability | 60 % (approx) |
| Protein Binding | 0 % |
| Volume of Distribution | 0.1 L/kg (approx) |
| Clearance Route | other |
| Active Metabolites | no |
| Notes | Dose in units. Very flat profile; allows flexible injection timing once daily. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Hypoglycemia, weight gain, injection-site reactions
Contraindications:
Hypoglycemia unawareness (relative)
Precautions:
Educate flexibility but keep consistent timing; standard hypo education