Ciprofloxacin
Brand: Cipro (US/EU) / Cifran (IN) / Ciprogen (BD)
Antibiotic
Fluoroquinolone
Pharmacokinetics
| Half-life | 4 hours |
| Tmax | 2 h |
| Bioavailability | 70 % (approx) |
| Protein Binding | 30 % |
| Volume of Distribution | 2 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | High tissue distribution; adjust in renal impairment; avoid with calcium/iron/zinc within 2 hours. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Tendonitis, tendon rupture, CNS effects, QT prolongation, dysglycemia
Contraindications:
Children, pregnancy (relative), history of tendon rupture with quinolones
Precautions:
Avoid combining with steroids due to tendon risk; caution in elderly and seizures