Flumazenil
Brand: Romazicon (US/EU)
Emergency
Benzodiazepine antagonist
Pharmacokinetics
| Half-life | 1 hours |
| Tmax | 0.15 h |
| Bioavailability | 0 % (approx) |
| Protein Binding | 80 % |
| Volume of Distribution | 1 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Use with extreme caution; seizures risk high especially if patient used tricyclic antidepressants or chronic BZD use. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
Seizures, agitation, arrhythmias
Contraindications:
Mixed TCA overdose; chronic BZD dependent patients
Precautions:
Not routinely used; only if isolated benzodiazepine overdose under controlled setting