Rosuvastatin
Brand: Crestor (US/EU) / Rosuvas (IN) / Rosumix (BD)
Cardiovascular
Statin (HMG-CoA reductase inhibitor)
Pharmacokinetics
| Half-life | 19 hours |
| Tmax | 3 h |
| Bioavailability | 20 % (approx) |
| Protein Binding | 88 % |
| Volume of Distribution | 0.13 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Hydrophilic; minimal CYP metabolism (CYP2C9 small contribution); lower drug interactions than atorvastatin. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Myalgia, ALT elevation, rare rhabdomyolysis
Contraindications:
Pregnancy, active liver disease
Precautions:
Start 5mg in Asian ethnicity due to higher exposure; check LFT if symptoms appear