Simvastatin
Brand: Zocor (US/EU) / Simvotin (IN) / Simvas (BD)
Cardiovascular
Statin (HMG-CoA reductase inhibitor)
Pharmacokinetics
| Half-life | 2 hours |
| Tmax | 1.3 h |
| Bioavailability | 5 % (approx) |
| Protein Binding | 95 % |
| Volume of Distribution | 0.12 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Short t½ but strong hepatic extraction; very high CYP3A4 interaction; avoid high dose with clarithro. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Myopathy, liver enzyme rise, GI discomfort
Contraindications:
Pregnancy, active liver disease
Precautions:
Avoid macrolides and azoles; do not exceed 20 mg/day with amlodipine or verapamil