Abemaciclib
Brand: Verzenio
Anticancer
CDK4/6 inhibitor
Pharmacokinetics
| Half-life | 18 hours |
| Tmax | 6 h |
| Bioavailability | 45 % (approx) |
| Protein Binding | 96 % |
| Volume of Distribution | 2.5 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Higher GI toxicity (diarrhoea) vs palbociclib/ribociclib; consider prophylactic antidiarrhoeal. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Diarrhoea, neutropenia, fatigue
Contraindications:
severe hepatic impairment
Precautions:
early diarrhoea management crucial