Trastuzumab
Brand: Herceptin (global) / Trastuzumab (IN/BD)
Anticancer
HER2 monoclonal antibody
Pharmacokinetics
| Half-life | 684 hours |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | RAW70: 6 mg/kg q21 days → ~420 mg. Loading dose 8 mg/kg recommended initially. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Cardiomyopathy, infusion reactions, pulmonary toxicity
Contraindications:
Severe heart failure
Precautions:
Baseline and periodic echocardiography; monitor LVEF
Half-life approx 28.5 days → 28.5×24 = 684 hours
dosing is weight based: 8 mg/kg loading, then 6 mg/kg every 3 weeks
for RAW70 (70 kg adult) → 6×70 = 420 mg every 3 weeks