Ceritinib

Brand: Zykadia (global)

Anticancer ALK inhibitor (2nd generation)

Chemistry

Molecular Formula	C28H36N5ClO3
PubChem	CID: 57379313 Open in PubChem

Structure

Half-life	1.7 days
Tmax	6 h
Protein Binding	97 %
Volume of Distribution	423 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	yes
Notes	Take with food to improve tolerability; strong CYP3A substrate and inhibitor.

Severity: Moderate

Adverse Effects:
Severe GI toxicity (diarrhea, nausea), hepatotoxicity, QT prolongation, hyperglycemia

Contraindications:
Severe hepatic impairment

Precautions:
ECG and glucose monitoring; reduce dose if intolerable

Half-life ~41 hours ≈ 1.7 days
Max dose often 450 mg/day with food