Entrectinib

Brand: Rozlytrek (global)

Anticancer NTRK / ROS1 inhibitor

Chemistry

Molecular Formula	C31H34F2N6O2
PubChem	CID: 57368586 Open in PubChem

Structure

Half-life	20 hours
Tmax	4 h
Protein Binding	99 %
Volume of Distribution	12.4 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	yes
Notes	Good CNS penetration. Substrate of CYP3A. Avoid grapefruit.

Severity: Moderate

Adverse Effects:
Edema, dizziness, cognitive changes, weight gain, hepatotoxicity, CHF risk

Contraindications:
Severe uncontrolled HF

Precautions:
Monitor weight, CNS symptoms, LFT. Consider baseline and periodic cardiac function evaluation.