Anastrozole
Brand: Arimidex (global)
Endocrine
Aromatase inhibitor
Pharmacokinetics
| Half-life | 50 hours |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Standard dose 1 mg/day; no advantage to higher dose. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Bone loss, hot flashes, arthralgias
Contraindications:
Premenopausal without ovarian suppression
Precautions:
Monitor BMD, consider bisphosphonate/denosumab prophylaxis