Vincristine

Brand: Cytocristin (IN/BD) / Oncovin (global)

Anticancer Vinca alkaloid (microtubule inhibitor)

Chemistry

Molecular Formula	C46H56N4O10
PubChem	CID: 5978 Open in PubChem

Structure

Half-life	85 hours
Clearance Route	hepatic
Active Metabolites	no
Notes	Dose limiting toxicity is neurotoxicity rather than myelosuppression.

Severity: Severe

Adverse Effects:
Peripheral neuropathy, constipation/ileus, jaw pain, cranial nerve palsies

Contraindications:
Demyelinating Charcot-Marie-Tooth neuropathy

Precautions:
Prevent constipation aggressively; do NOT give intrathecal (fatal).