Paclitaxel

Brand: Taxol (global) / Paclitax (IN/BD)

Anticancer Taxane (microtubule stabilizer)

Chemistry

Molecular Formula	C47H51NO14
PubChem	CID: 36314 Open in PubChem

Structure

Half-life	20 hours
Clearance Route	hepatic
Active Metabolites	yes
Notes	Requires premedication to prevent hypersensitivity due to Cremophor EL formulation; adjust in hepatic impairment.

Severity: Severe

Adverse Effects:
Neutropenia, peripheral neuropathy, hypersensitivity reactions, alopecia

Contraindications:
Baseline severe neutropenia

Precautions:
Premedicate with steroid + H1/H2 blocker; monitor CBC