Idarubicin

Brand: Idamycin (global)

Anticancer Anthracycline (topoisomerase II inhibitor)

Chemistry

Molecular Formula	C26H27NO9
PubChem	CID: 60877 Open in PubChem

Structure

Half-life	22 hours
Clearance Route	hepatic
Active Metabolites	yes
Notes	More lipophilic → better intracellular penetration; lifetime dose limit applies.

Severity: Life-threatening

Adverse Effects:
Cardiotoxicity, myelosuppression, nausea/vomiting, mucositis

Contraindications:
Severe cardiac dysfunction

Precautions:
Monitor EF + CBC; lifetime anthracycline dose limit applies