Isoprenaline
Brand: Isuprel
Sympathomimetic
Non-selective β-agonist
Pharmacokinetics
| Half-life | 0.05 hours |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Extensive first-pass metabolism by COMT; t½ ~2–5 min |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Tachycardia, palpitations, arrhythmias, flushing, tremor, headache, hypotension
Contraindications:
Tachyarrhythmias, digitalis-associated arrhythmias
Precautions:
Caution in ischemic heart disease, hyperthyroidism, elderly, and in combination with MAO inhibitors