Midodrine
Brand: ProAmatine / Gutron
Sympathomimetic
Alpha-1 selective agonist
Pharmacokinetics
| Half-life | 0.5 hours |
| Clearance Route | renal |
| Active Metabolites | yes |
| Notes | Active metabolite (desglymidodrine) t½ ≈ 3 hours. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Supine hypertension, piloerection, pruritus, urinary retention
Contraindications:
Severe organic heart disease, acute renal disease
Precautions:
Avoid dosing close to bedtime due to supine hypertension risk