Ivermectin

Brand: Stromectol / Ivermectin (generic)

Antiparasitic Macrocyclic lactone (Avermectin)

Chemistry

Molecular Formula	C48H74O14
PubChem	CID: 6321424 Open in PubChem

Structure

Half-life	18 hours
Clearance Route	hepatic
Active Metabolites	Minor metabolites via CYP3A4
Notes	Avoid in severe Loa Loa infection due to risk of encephalopathy. Use caution in hepatic impairment.

Severity: Moderate

Adverse Effects:
Dizziness; pruritus; rash; lymphadenitis; Mazzotti reaction in onchocerciasis

Contraindications:
Pregnancy (relative); Children < 15 kg; Meningitis or impaired BBB

Precautions:
Check for Loa loa co-endemicity; Caution in elderly; Monitor for neurological symptoms