Fondaparinux

Brand: Arixtra (US/EU) / Fondared (IN) / Fondazest (IN) / Fondaplex (BD)

Anticoagulant Synthetic factor Xa inhibitor (parenteral)

Chemistry

Molecular Formula	C31H43N3O49S8
PubChem	CID: 16132231 Open in PubChem

Structure

Half-life	17 hours
Tmax	2 h
Bioavailability	100 % (approx)
Volume of Distribution	0.07 L/kg (approx)
Clearance Route	renal
Active Metabolites	no
Notes	Once-daily dosing; fully synthetic (no HIT risk); avoid in severe renal impairment (CrCl <30).

Severity: Moderate

Adverse Effects:
Bleeding, injection-site hematoma, anemia

Contraindications:
Severe renal impairment (CrCl <30), active bleeding, bacterial endocarditis

Precautions:
Safer alternative in patients with history of HIT; no antidote available; avoid neuraxial anesthesia timing errors