Tinidazole
Brand: Tindamax (US) / Fasigyn (Global)
Antiparasitic
Nitroimidazole Antiprotozoal
Pharmacokinetics
| Half-life | 12.5 hours |
| Clearance Route | hepatic |
| Active Metabolites | minor |
| Notes | Longer half-life than metronidazole; mainly used for protozoal infections. Avoid in 1st trimester pregnancy; caution with alcohol (disulfiram-like effect controversial but advised). |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Metallic taste, nausea, fatigue, dizziness; rare peripheral neuropathy; dark urine.
Contraindications:
1st trimester pregnancy, breastfeeding, hypersensitivity to nitroimidazoles.
Precautions:
Avoid alcohol; caution in hepatic disease; prolonged courses increase neuropathy risk.