| Half-life | 12 hours |
| Clearance Route | hepatic |
| Active Metabolites | minor |
| Notes | Long half-life allows once- or twice-daily dosing. Avoid alcohol. Caution in hepatic impairment and long-term use (risk of neuropathy). |
Severity: Moderate
Adverse Effects:
Nausea, metallic taste, dizziness, fatigue; rarely seizures or neuropathy.
Contraindications:
1st trimester pregnancy, hypersensitivity to nitroimidazoles.
Precautions:
Avoid alcohol; monitor for neurologic symptoms in prolonged therapy.